The incidence of anorectal STIs has risen in recent years, a trend primarily attributed to an increase in the practice of anal receptive intercourse. This article reviews STIs of the anus and rectum, examining their epidemiology, presentation, and management.Īnorectal STIs are commonly the result of anal receptive intercourse but may also be due to contiguous spread from a genital infection. Patients with anorectal symptoms or lesions are often referred to colorectal surgeons for complete evaluation or management. Anorectal involvement is common, although the exact prevalence remains unknown due to numerous asymptomatic infections and a lack of accurate epidemiologic data. In the United States (US), the annual incidence reaches approximately 15 million cases. Sexually transmitted infections (STIs) are a substantial health concern, with an estimated worldwide incidence of 333 million cases per year.